Personal construct therapy for hiv seropositive patients plus#
If their viral load had declined to below 400 or by more than 0.5 logs since their first screen, then they were put straight into a non-randomised group in which they received open-label lenacapavir plus the best combination of other drugs, including other investigatory ones, that could be devised given their resistance profile (a so-called optimised background regimen or OBR). After they were enrolled, they were screened a second time. This week Professor Jean-Michel Molina of Hôpital Saint-Louis in Paris presented results from the first six months of CAPELLA – of efficacy in the group of participants randomised initially to receive either lenacapavir or a placebo, and of safety in all study participants.Īltogether, 72 people were enrolled in the study.
This found that during the initial two weeks of the study, 88% of participants receiving lenacapavir experienced at least a 0.5 log (more than threefold) drop in their viral load, compared with just 17% of those given a placebo.
At this year's Conference on Retroviruses and Opportunistic Infections (CROI) in March, the first results were announced from the CAPELLA study, which is investigating the safety and efficacy of lenacapavir in a group of highly treatment-experienced people with extensively drug-resistant HIV whose current antiretroviral therapy (ART) regimens were failing. Its remarkable longevity in the body was first presented to conferences in 2019 when it still only had the investigatory name of GS-6207.
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